This key is decided by spider-control discipline: protect the planned kick, do not accidentally chain nearby packs, and clear boss adds before they turn into permanent pressure.
Hold a kick for Ixin's Horrifying Shrill and never let a Sentry Stagshell finish Alarm Shrill. Web Bolt is a spare-kick spell; the fear and alarm are the casts that change the pull.
Kill or crowd-control Starved Crawlers before they reach Avanoxx. If she consumes one, Insatiable stacks and the pull rapidly becomes a healing and tank-survival problem. Use personals for Alerting Shrill and keep Vile Webbing out of the group path.
The Bloodstained Webmage's Revolting Volley is the priority kick before Anub'zekt. On the boss, use a defensive for Infestation, place the resulting swarm away from future movement, and interrupt Silken Restraints while cleaving the Webmages together.
These are execution priorities, not a fixed pull-count route. Verify weekly tuning, affixes, and your tank's route before the key, then use the source and current videos for difficulty-specific details.
Keep the arena traversable: sidestep Erupting Webs and do not turn the last boss into a rushed movement check by dropping avoidable ground effects in the center.